Arindam Mukherjee

Share it A supremely talented sportsman trying to make it big while surviving the hardships of life.

Artificial Intelligence (AI) is rapidly transforming the way people learn, work, and build careers.For students and young professionals, this shift

Share it The truth is, everyone is going to hurt you. You just got to find the ones worth suffering for. – Bob Marley

Hiring decisions have traditionally relied on degrees, resumes, and institutional reputation to evaluate candidates.

In my colony, when everyone is in a rush to leave for office in the morning, there is always a ruckus. The subject: Wrong car parking and blocking exit points…

An evolving method of hiring for labour in India is through a structural reform in the hiring landscape, with the gradual move towards skill and readiness for work as opposed to prior educational standards or qualifications.

Share it In his stand-up special Besharam, Abhishek Upmanyu brought up a topic that is still one of the biggest unsolved issues in Indian households.

The cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS–STING) pathway is a central regulator of antitumor immunity, capable of converting immunologically “cold” tumors into inflamed, immune-responsive states. Cyclic dinucleotide (CDN) agonists have clinically validated the impact of targeting this axis but are limited by poor pharmacokinetics, limited tumor penetration, and delivery challenges. Non-CDN based small-molecule modulators such as MSA-2 and amidobenzimidazole (ABZI) directly modulate cGAS–STING signaling. Beyond direct receptor agonism, coupling with metals offer platforms with complementary strategies to engage and amplify cGAS–STING signaling. Complexes incorporating platinum, ruthenium, iridium, rhodium, gold, copper, manganese, or zinc exploit redox activity, coordination versatility, and photophysical properties to induce nuclear or mitochondrial DNA stress, disrupt organelle homeostasis, and promote immunogenic cell death. By coupling STING activation to ferroptosis, pyroptosis, or cuproptosis, these complexes form the foundation of self-emerging design principles with elaborate mechanistic insights, and translational challenges shaping immune modulation for therapeutics.

A sunitinib-derived Ru(II) hydrazide complex enables ROS-independent immunogenic cell death through multi-target protein engagement. Concurrent inhibition of VEGFR2, NF-κB, and telomerase induces ER–mitochondrial stress and calreticulin exposure. Folate-targeted micellar delivery enhances tumor selectivity and suppresses tumor growth with increased T-cell infiltration in vivo.

A sunitinib-derived Ru(II) hydrazide complex enables ROS-independent immunogenic cell death through multi-target protein engagement. Concurrent inhibition of VEGFR2, NF-κB, and telomerase induces ER–...