Jeremy Chen

A deadly police shooting during a welfare check in Bristol is putting into focus the risks officers face when responding to calls involving people who may be armed.

Police said the employee was trying to get to work when an armed man attempted to carjack him. The victim fought back, leading to the shooting.

Clostridioides difficile infection (CDI) is a leading cause of antibiotic-associated diarrhea, yet most microbiome studies have focused on bacterial composition, overlooking fungal contributions and transcriptionally active functions. Here, we applied matched metagenomic (MG) and metatranscriptomic (MT) sequencing to diarrheal stool from 100 adults (50 CDI+, 50 CDI−) to characterize taxonomic structure, functional potential and expression, predicted metabolites, and bacterial–fungal interactions. CDI− samples exhibited relatively greater taxonomic evenness, whereas CDI+ samples showed relatively higher MT KEGG Ortholog richness, indicating broader transcriptional activity. Beta diversity analyses demonstrated significant separation by CDI status, strongest in MT functional profiles. CDI+ microbiomes were enriched for opportunistic and transcriptionally active taxa, including C. difficile, Lactococcus cremoris, Nitratidesulfovibrio vulgaris, and fungi such as Candida albicans and Nakaseomyces glabratus, while CDI− communities were relatively enriched for obligate anaerobic commensals (e.g., Faecalibacterium, Roseburia, Subdoligranulum). Functionally, CDI+ communities were relatively enriched in transport, stress-response, motility, quorum sensing, and amino acid metabolism pathways, whereas CDI− retained core metabolic functions. Network analyses identified significant enrichment of fungal-commensal co-exclusion relationships in the CDI+ metatranscriptomic network relative to CDI-, and predicted metabolites implicated bile acid disruption and lipid remodeling. Together, these findings define CDI as a trans-kingdom, functionally reprogrammed ecosystem and highlight the importance of integrating fungal ecology and transcriptional activity in CDI pathogenesis.

According to a survey conducted by UConn and Connecticut Foodshare, more than half of households that visit food pantries have children, while about one-third report having jobs.

Her book celebrates diversity and teaches children that being a princess is about more than physical appearance.

With Halloween just days away, families around Connecticut are heading to local pumpkin patches to find the perfect pumpkin, even as rising costs make the seasonal tradition more expensive.

A Connecticut high school student is turning his love for tennis into an opportunity to give back by collecting tennis rackets and pickleball paddles for people in Uganda.

CCADV is also working with the state Division of Criminal Justice to create a task force that would examine state crime data and develop recommendations to address family violence.

Evallice "Evie" Torres was struck by a car while crossing the intersection of New Britain Avenue and Zion Street in Hartford on her way to school on Sept. 29. She suffered multiple broken bones and torn ligaments.

Connecticut currently has 670 school librarians, down about 7% from four years ago, equivalent to a loss of about 80 positions.