Shivam Damohe

Patrick Mahomes' 2025 season ended in the worst possible way. With less than two minutes remaining in a Week 15 loss to the Los Angeles Chargers, a

Peyton and Eli Manning are kicking off their sixth season of the ManningCast with a guest list built entirely around tonight's matchup.

Thursday Night Football is on tonight. Lions at Bills kicks off at 8:15 p.m. ET on Prime Video, both teams come in 1-0 in Week 2's marquee matchup.

Thursday Night Football is on tonight, and it’s a good one. The Detroit Lions travel to Buffalo to face the Bills in the first regular-season game ever played at the Bills’ new Highmark Stadium.

There are no NFL games on Friday. Buffalo beat Detroit 41-31 to open Week 2. Here's the full remaining schedule and streaming details.

There are no NFL games on Saturday, September 19. Buffalo beat Detroit 41-31 to open Week 2. Here's the full remaining schedule and streaming details.

The Colts take on the Chiefs in Sunday Night Football tonight. Here's the full Week 2 schedule for all 14 games, streaming details, and top matchups to watch.

Monday Night Football closes out Week 2 tonight. The New York Giants take on the Los Angeles Rams at 8:15 p.m. ET.

The New York Giants travel to face the Los Angeles Rams, capping a week that already delivered Thursday’s Bills-Lions opener and a full 14-game Sunday slate topped by Colts-Chiefs on Sunday Night Football. Tonight’s matchup carries its own intrigue as New York arrives fresh off a Week 1 Sunday Night Football win, while the Rams are playing their first home game since their season-opening trip to Melbourne, Australia.

Bryan Cranston, Aaron Paul, Jeremy Shockey and Andrew Whitworth join Peyton and Eli Manning tonight for Giants-Rams. Here's the full ManningCast guest breakdown.