Matthew J.

Whole-genome sequencing (WGS) can provide important benefits to childhood cancer patients, but clinical WGS workflows typically take weeks. Here, the authors evaluate the feasibility and efficacy of a rapid WGS research workflow with streamlined bioinformatics, reducing the mean turnaround time from 42 to 3 days without sacrificing the detection of clinically actionable variants.

SRSF2 mutations occur in 5–15% of acute myeloid leukemia (AML) and ~15% of myelodysplastic neoplasms (MDS), are enriched in elderly/secondary AML, and lack mutation-directed therapy.

BPL-1357 has shown broad protection in animal models against influenza viruses. The authors demonstrate safety of the vaccine given intramuscularly or intranasally in healthy adults in a phase I trial and characterize the elicited immune responses.

Genetic studies in Caenorhabditis elegans have established core principles of RAS-MAPK signalling.

Sereda and colleagues show that chaperone-mediated autophagy declines with aging, which leads to enhanced senescent cell burden that is driven, in

New studies of trends in the global burden of measles and pertussis offer a reminder of how much vaccination has achieved and a warning of the need to build more resilient and sustainable vaccination programs.

I introduce value-dependent spite into first-price all-pay auctions and demonstrate that it leads to overbidding. Unlike in first- and second-price winner-pay auctions, value-dependent spite does not change the basic curvature of equilibrium bids: they remain convex. Nonetheless, value-dependent spite predicts different overbidding patterns from those predicted by value-independent spite. My main result highlights that, for low values, equilibrium bids when spite is value-dependent are closer to the non-spiteful benchmark than when spite is value-independent. Using approximations, I show that this result is strengthened when the relationship between a bidder’s value and her degree of spite is convex and weakened when it is concave.

The flavivirus nonstructural protein 5 performs multiple functions during infection, including RNA replication and type I interferon signaling antagonism.

Phase 1 of TenK10K takes single-cell RNA sequencing and matched whole-genome sequencing data from 1,925 individuals, enabling detection of associations for common and rare genetic variants, the latter of which have been uncharacterized in their impact on cell-specific gene expression.

A skin-mounted magnetometer array that wirelessly tracks implanted magnetic beads enables precise neuromuscular sensing and neuroprosthetic control that match or exceed those achievable with electromyography.